Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F07%3A00006690" target="_blank" >RIV/00216208:11160/07:00006690 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/07:00001769

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase

Original language description

Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203); the knownreactivators (pralidoxime, HI-6, obidoxime, K075, K203) and the new compounds were tested in vitro on a model of tabun- and paraoxon-inhibited AChE

Czech name

Monooximové reaktivátory acetylcholinesterasy s (E)-but-2-enovým můstkem - Příprava a reaktivace tabunem a paraoxonem inhibované acetylcholinesterasy

Czech description

Bylo vyvinuto patnáct nových monooximových reaktivátorů acetylcholinesterázy s (E)-but-2-enovým můstkem ve snaze rozšířit vlastnosti K-oximu (E)-1-(4-karbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-en dibromidu (K203); známé reaktivátory (pralidoxime, HI-6, obidoxime, K075, K203) a nové sloučeniny byly testovány in vitro na modelu tabunem a paraxonem inhibované AChE

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/OPUOFVZ200603" target="_blank" >OPUOFVZ200603: A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic and Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

21

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

6733-6741

UT code for WoS article

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EID of the result in the Scopus database

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