Monoquarternary pyridinium salts with modified side chain - synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F08%3A00109176" target="_blank" >RIV/00216208:11160/08:00109176 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/08:00002002
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Monoquarternary pyridinium salts with modified side chain - synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase
Original language description
Eighteen monoquarternary reactivators of acetylcholinesterase with modified side chain were developed; the compounds were tested on a model of tabun- and paraoxon-inhibited AChE; the compounds were not able to exceed the best known compounds for tabun poisining, but some did show reactivation better or comparable with pralidoxime for paraoxon poisoning
Czech name
Monokvarterní pyridiniové soli s modifikovaným postranním řetězcem - syntéza a hodnocení na modelu tabunem a paraoxonem inhibované acetylcholinesterasy
Czech description
Bylo vyvinuto 18 monokvarterních reaktivátorů acetylcholinesterasy s modifikovaným postranním řetězcem; sloučeniny byly testovány na modelu tabunem- a paraoxonem-inhibované AChE; proti intoxikaci tabunem nebyly účinnější než nejlepší známé reaktivátory,ale některé z nich vykázaly reaktivaci lepší nebo srovnatelnou s pralidoximem proti intoxikaci paraoxonem
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ME%20865" target="_blank" >ME 865: Countermeasure against chemical terrorism - development of new antidotes against nerve agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic & Medicinal Chemistry
ISSN
0968-0896
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
000258827800041
EID of the result in the Scopus database
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