Liquid chromatographic-electrospray mass spectrometric determination (LC-ESI-MS) of phase II metabolites of flobufen in rat liver microsomes - Chiral discrimination
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F08%3A00109188" target="_blank" >RIV/00216208:11160/08:00109188 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Liquid chromatographic-electrospray mass spectrometric determination (LC-ESI-MS) of phase II metabolites of flobufen in rat liver microsomes - Chiral discrimination
Original language description
Glucuronidation of flobufen and its major metabolite M17203 has been implicated as an important mechanism of flobufen elimination; o-glucuronides were identified in rat liver microsomes and different enzyme kinetics for two enantiomers was found
Czech name
LC-ESI-MS určení metabolitů flobufenu II. fáze v mikrosomech potkana - Chirální rozlišení
Czech description
Významným eliminačním mechanismem pro flobufen je glukuronace parentní molekuly i jeho hlavního metabolitu M17203; v jaterních mikrosomech potkana byly nalezeny o-glukuronidy flobufenu, jehož enantiomers vykazovaly rozdílné enzymové kinetiky
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Talanta
ISSN
0039-9140
e-ISSN
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Volume of the periodical
75
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
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UT code for WoS article
000255270700026
EID of the result in the Scopus database
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