Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F09%3A00210081" target="_blank" >RIV/00216208:11160/09:00210081 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin

Original language description

In this study it was purified a new membrane-bound carbonyl reductase from human liver microsomes that takes part to biotransformation of anticancer drug oracin. Determined kinetic parameters for this enzyme and oracin are several times better than the same parameters for 11beta-HSD1 that is currently only one well-known microsomal carbonyl reductase contributing to metabolism of xenobiotics.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA303%2F07%2F0994" target="_blank" >GA303/07/0994: Targeting the novel human microsomal reductases causing resistance in cancer chemotherapy.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology

ISSN

0300-483X

e-ISSN

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Volume of the periodical

264

Issue of the periodical within the volume

1-2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

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UT code for WoS article

000270531400007

EID of the result in the Scopus database

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