Preparation and in vitro evaluation of monoquaternary inhibitors of brain cholinesterases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F09%3A00210088" target="_blank" >RIV/00216208:11160/09:00210088 - isvavai.cz</a>
Alternative codes found
RIV/44555601:13440/09:00004897 RIV/60162694:G44__/09:00002157
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Preparation and in vitro evaluation of monoquaternary inhibitors of brain cholinesterases
Original language description
Acetylcholinesterase inhibitors are currently of high interest due to the many reasons. Among them, Alzheimer's disease drugs are of great interest. In this study, eleven mono quarternary pyridinium salts substituted by different groups (electron donorsand electron acceptors) in position four were prepared. Then, their anticholinesterase was tested. As observed, their IC50 ranged from 33 ?M to 3981 ?M. Moreover, probability of blood-brain barrier penetration was predicted.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Letters in Organic Chemistry
ISSN
1570-1786
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
6
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
4
Pages from-to
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UT code for WoS article
000271615100015
EID of the result in the Scopus database
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