Antiviral Activity of Substituted Salicylanilides - A Review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F11%3A10099476" target="_blank" >RIV/00216208:11160/11:10099476 - isvavai.cz</a>

Result on the web

<a href="http://www.ingentaconnect.com/content/ben/mrmc/2011/00000011/00000011/art00003" target="_blank" >http://www.ingentaconnect.com/content/ben/mrmc/2011/00000011/00000011/art00003</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Antiviral Activity of Substituted Salicylanilides - A Review

Original language description

Salicylanilides demonstrated a wide range of biological activities including antiviral potency and the review summarizes this field. Niclosamide was described to be able to affect coronaviruses. Some salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus is another virus, which could be potentially afflicted by salicylanilides on the level of two enzymes - NS3 protease and NS5B RNA polymerase. Nitazoxanide is a nitrothiazolederivative of salicylamide useful for the treatment of protozoal and bacterial infections with an extended range of antiviral activity and innovative mechanism of action, especially against hepatitis and influenza viruses or rotaviruses. Nitazoxanide, its metabolite tizoxanide and their derivatives are a very promising stream in the development of new antiviral compounds. In this review, we summarize the antiviral activity of structures containing salicylanilide and partly salicylamide m

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/NS10367" target="_blank" >NS10367: Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mini reviews in medicinal chemistry

ISSN

1389-5575

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

11

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

956-967

UT code for WoS article

000294704600003

EID of the result in the Scopus database

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