Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F11%3A10100471" target="_blank" >RIV/00216208:11160/11:10100471 - isvavai.cz</a>
Result on the web
<a href="http://www.prolekare.cz/ceska-slovenska-farmacie-clanek?id=34296" target="_blank" >http://www.prolekare.cz/ceska-slovenska-farmacie-clanek?id=34296</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model
Original language description
99mTc-MAG3 and 99mTc-DMSA are renal radiodiagnostics in clinical use. However, the renal mechanisms determining their transport within the kidney are not fully explained. The investigation compared renal uptake of the studied compounds and evaluated contribution of active and passive transport mechanisms to the renal accumulation. As the experimental model, freshly isolated rat renal cells were used. The results documented significant quantitative and qualitative differences between the tested agents. The found data indicated that 99mTc-DMSA was transported across the membranes of the renal cells almost exclusively by passive transport. On the other side, 99mTc-MAG3 accumulation rate in the rat renal cells was several times higher and was mediated by active transport mechanisms.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Česká a slovenská farmacie
ISSN
1210-7816
e-ISSN
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Volume of the periodical
60
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
7-10
UT code for WoS article
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EID of the result in the Scopus database
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