Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage - Implications for early Myasthenia gravis treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F11%3A10100530" target="_blank" >RIV/00216208:11160/11:10100530 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/11:00002425 RIV/44555601:13440/11:43878438
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0223523410008676" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0223523410008676</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2010.12.011" target="_blank" >10.1016/j.ejmech.2010.12.011</a>
Alternative languages
Result language
angličtina
Original language name
Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage - Implications for early Myasthenia gravis treatment
Original language description
This paper describes preparation and in vitro evaluation of 20 newly prepared bis-isoquinolinium inhibitors of potential concern for Myasthenia gravis (MG). The newly prepared compounds were evaluated in vitro on human recombinant acetylcholinesterase (AChE) and human plasmatic butyrylcholinesterase (BChE). Their inhibitory ability was expressed as IC50 and compared to chosen standards ambenonium dichloride, edrophonium chloride, BW284c51 and ethopropazine hydrochloride.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP203%2F09%2FP130" target="_blank" >GP203/09/P130: Development of novel acetylcholinesterase inhibitors as treatment of Myasthenia Gravis</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Medicinal Chemistry
ISSN
0223-5234
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
811-818
UT code for WoS article
000287617500038
EID of the result in the Scopus database
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