Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites - The cardioprotectant dexrazoxane as a model case

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F11%3A10100602" target="_blank" >RIV/00216208:11160/11:10100602 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0021967310016249" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0021967310016249</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chroma.2010.11.050" target="_blank" >10.1016/j.chroma.2010.11.050</a>

Result language
angličtina
Original language name
Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites - The cardioprotectant dexrazoxane as a model case
Original language description
Hydrophilic interaction liquid chromatography (HILIC) was used to analyze dexrazoxane and its three metabolites on different stationary phases. Initial experiments were done with HPLC-UV and subsequently LC-MS were used to confirm applicability of the selected conditions. In addition, LC-MS behavior of all analytes were studied and characterized.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GPP206%2F10%2FP439" target="_blank" >GPP206/10/P439: Modern bioanalytical contribution to the interdisciplinary investigation of bisdioxopiperazine cardioprotective agents.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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