Synthesis and Functionalization of 5-Substituted Tetrazoles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124481" target="_blank" >RIV/00216208:11160/12:10124481 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201200469/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201200469/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201200469" target="_blank" >10.1002/ejoc.201200469</a>

Result language
angličtina
Original language name
Synthesis and Functionalization of 5-Substituted Tetrazoles
Original language description
Tetrazoles are synthetic heterocycles with numerous applications in organic chemistry, coordination chemistry, the photographic industry, explosives, and, in particular, medicinal chemistry. In organic chemistry, 5-substituted tetrazoles are used as advantageous intermediates in the synthesis of other heterocycles and as activators in oligonucleotide synthesis. In drug design, 5-monosubstituted tetrazoles are the most important tetrazole derivatives because they represent nonclassical bioisosteres of carboxylic acids, with similar acidities but higher lipophilicities and metabolic resistance. In this review we focus on the preparation and further functionalization of these heterocycles.
Czech name
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Czech description
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Project
<a href="/en/project/GAP207%2F10%2F2048" target="_blank" >GAP207/10/2048: Chiral Quinazoline Alkaloids: Potential Prototypes of Novel Antiasthmatics and Organocatalysts</a>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP) S - Specificky vyzkum na vysokych skolach I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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