Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10124671" target="_blank" >RIV/00216208:11160/12:10124671 - isvavai.cz</a>

Result on the web

<a href="http://www.woundsresearch.com/article/preclinical-evaluation-wound-treatment-hyaluronan-iodine-hydrogel" target="_blank" >http://www.woundsresearch.com/article/preclinical-evaluation-wound-treatment-hyaluronan-iodine-hydrogel</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel

Original language description

A mixture of hyaluronan and iodine complex Kl(3) (Hyiodine (R)) has been developed to support wound healing. In this study, the effect of hyaluronan, Kl(3), and their combination on progression of wound healing in excision skin wounds in rats was determined. Methods. To evaluate the possible toxic effects of iodine after Hyiodine application for wound healing, iodine systemic absorption from the Hyiodine-treated wounds and its distribution profile were quantitatively described and compared after intravenous iodide administration using I-131 as a radiolabel. Results. Treatment of rats with Hyiodine resulted in an enhancement of wound healing, proved by greater degrees of wound contraction and reduction in mean wound healing time compared to other treated rats on hours 1, 2, 24, and 216. Even if wound therapy with Hyiodine resulted in systemic iodine uptake, the estimated iodine absorbed dose in human therapy is tolerable, and the theoretical risk of its systemic toxic effects is minimal

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Wounds

ISSN

1044-7946

e-ISSN

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Volume of the periodical

24

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

267-274

UT code for WoS article

000308778300006

EID of the result in the Scopus database

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