A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F12%3A10144110" target="_blank" >RIV/00216208:11160/12:10144110 - isvavai.cz</a>

Result on the web

<a href="http://www.eurekaselect.com/108094/article" target="_blank" >http://www.eurekaselect.com/108094/article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1872312811206030004" target="_blank" >10.2174/1872312811206030004</a>

Result language

angličtina

Original language name

A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK

Original language description

Tobacco smoking is the most widely known cause of human cancer-related death worldwide. NNK is one of the proved human carcinogens contributing to the development of several types of cancer. The carcinogenic effect of NNK depends on the metabolic pathway. Reduction of NNK by carbonyl reducing enzymes leads to the formation of NNAL. This pathway is generally regarded as detoxification pathway although the conditions and circumstances are quite complicated-the process depends on a formed enantiomer of NNAL. In this study a novel method for the determination of the metabolite NNAL was developed. This makes it possible to find and characterize carbonyl reducing enzymes that are involved in NNK metabolism. This simple HPLC method uses conventional HPLC instrumentation and is designed mainly for biochemical laboratories. A new microsomal carbonyl reducing enzyme participating in the metabolism of NNK in vitro has been described. Its activity was compared with other carbonyl reducing enzymes

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Drug Metabolism Letters

ISSN

1872-3128

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

174-181

UT code for WoS article

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EID of the result in the Scopus database

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