Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145614" target="_blank" >RIV/00216208:11160/13:10145614 - isvavai.cz</a>

Alternative codes found

RIV/71009396:_____/13:N0000003

Result on the web

<a href="http://www.mdpi.com/1420-3049/18/4/3674/pdf" target="_blank" >http://www.mdpi.com/1420-3049/18/4/3674/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules18043674" target="_blank" >10.3390/molecules18043674</a>

Result language

angličtina

Original language name

Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates

Original language description

The development of novel antimicrobial agents represents a timely research topic. Eighteen salicylanilide 4-(trifluoromethyl)benzoates were evaluated against Mycobacterium tuberculosis, M. avium and M. kansasii, eight bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA) and for the inhibition of mycobacterial isocitrate lyase. Some compounds were further screened against drug-resistant M. tuberculosis and for their cytotoxicity. Minimum inhibitory concentrations (MICs) for allmycobacterial strains were within 0.5-32 mu mol/L, with 4-chloro-2-[4-(trifluoromethyl)phenylcarbamoyl] phenyl 4-(trifluoromethyl) benzoate superiority. Grampositive bacteria including MRSA were inhibited with MICs }= 0.49 mu mol/L, while Gram-negative ones were much less susceptible. Salicylanilide 4-(trifluoromethyl) benzoates showed significant antibacterial properties, for many strains being comparable to standard drugs (isoniazid, benzylpenicillin) with no cross-resistance. All este

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

15

Pages from-to

3674-3688

UT code for WoS article

000318020100002

EID of the result in the Scopus database

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