Optimization of diclofenac sodium profile from halloysite nanotubules
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145715" target="_blank" >RIV/00216208:11160/13:10145715 - isvavai.cz</a>
Result on the web
<a href="http://www.prolekare.cz/linkout/40901" target="_blank" >http://www.prolekare.cz/linkout/40901</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Optimization of diclofenac sodium profile from halloysite nanotubules
Original language description
The main goal of this experiment was to optimize the dissolution profile of diclofenac sodium - a drug with problematic solubility - from halloysite tubules using various polymers. Loading of the drug together with povidone or Eudragit(R) RS did not leadto drug burst effect reduction and its slower dissolution. Reduction of the burst effect and further prolongation of drug release was achieved by coating the drug-loaded halloysite with chitosan. This formulation exhibited a diffusion-controlled prolonged release following Higuchi kinetic model.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Česká a slovenská farmacie
ISSN
1210-7816
e-ISSN
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Volume of the periodical
62
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
71-77
UT code for WoS article
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EID of the result in the Scopus database
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