Plasticized branched aliphatic oligoesters as potential mucoadhesive drug carriers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10145843" target="_blank" >RIV/00216208:11160/13:10145843 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0378517313009162" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0378517313009162</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2013.10.030" target="_blank" >10.1016/j.ijpharm.2013.10.030</a>

Result language
angličtina
Original language name
Plasticized branched aliphatic oligoesters as potential mucoadhesive drug carriers
Original language description
Three oligoesters with different molar mass and degree of branching, intended as drug carriers, were synthesized and their thermal, rheological, adhesive, and drug release properties were studied. Triethyl citrate, ethyl pyruvate, ethyl salicylate, methyl salicylate, triacetin and tributyrin at a concentration of 20% were tested as plasticizers to improve drug incorporation, and application of the polymeric system. All of the tested plasticizers significantly depressed the T-g by at least 25.5 degrees C. Plasticized oligoesters possessed remarkable adhesive properties on mucin in vitro, the adhesion is at least twofold bigger than it is for gels of cellulose derivatives. It was demonstrated that adhesivity increased with decreasing viscosity of oligoester matrices. In vitro dissolution tests of the flat matrices showed the prolongation of fluconazole release up to over 3 days for the oligoester carrier with the highest molar weight and degree of branching. Depending on the matrix hydro
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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