Ceramides in the Skin Lipid Membranes: Length Matters
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F13%3A10194157" target="_blank" >RIV/00216208:11160/13:10194157 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/13:43895951
Result on the web
<a href="http://pubs.acs.org/doi/full/10.1021/la4037474" target="_blank" >http://pubs.acs.org/doi/full/10.1021/la4037474</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/la4037474" target="_blank" >10.1021/la4037474</a>
Alternative languages
Result language
angličtina
Original language name
Ceramides in the Skin Lipid Membranes: Length Matters
Original language description
Ceramides are essential constituents of the skin barrier that allow humans to live on dry land. Reduced levels of ceramides have been associated with skin diseases, e.g., atopic dermatitis. However, the structural requirements and mechanisms of action ofceramides are not fully understood. Here, we report the effects of ceramide acyl chain length on the permeabilities and biophysics of lipid membranes composed of ceramides (or free sphingosine), fatty acids, cholesterol, and cholesterol sulfate. Short-chain ceramides increased the permeability of the lipid membranes compared to a long-chain ceramide with maxima at 4-6 carbons in the acyl. By a combination of differential scanning calorimetry, Fourier transform infrared spectroscopy, X-ray diffraction,Langmuir monolayers, and atomic force microscopy, we found that the reason for this effect in short ceramides was a lower proportion of tight orthorhombic packing and phase separation of continuous short ceramide-enriched domains with sho
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Langmuir : the ACS journal of surfaces and colloids
ISSN
0743-7463
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
50
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
15624-15633
UT code for WoS article
000328797500019
EID of the result in the Scopus database
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