Retention and selectivity of basic drugs on solid-phase extraction sorbents: Application to direct determination of beta-blockers in urine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10281834" target="_blank" >RIV/00216208:11160/14:10281834 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007/s00216-014-7753-4/fulltext.html" target="_blank" >http://link.springer.com/article/10.1007/s00216-014-7753-4/fulltext.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00216-014-7753-4" target="_blank" >10.1007/s00216-014-7753-4</a>

Result language
angličtina
Original language name
Retention and selectivity of basic drugs on solid-phase extraction sorbents: Application to direct determination of beta-blockers in urine
Original language description
Seven solid phase sorbent materials with reversed-phase, mixed-mode interactions (ion-exchange and reversed-phase), and molecularly imprinted polymers (MIP), namely Oasis HLB, Oasis MAX, Oasis MCX, Bond Elute Plexa, Bond Elute Plexa PAX, Bond Elute PlexaPCX, and SupelMIP sorbents, were investigated. The present study was focused on the retention and elution of pharmaceutically active substances based on several analyte-sorbent interaction properties. Basic drugs, such as beta-blockers (i.e., atenolol,pindolol, acebutolol, metoprolol, labetalol, and propranolol) were selected as the model compounds for this study. These compounds are frequently encountered in anti-doping tests. The extraction efficiencies of the individual sorbents were compared basedon the recovery of known amounts of the targeted analytes in a metered elution volume (500 mu L) in three separate elution fractions. The elution efficiency of the total amount of the target analytes on various sorbents was not appreciab
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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