In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10282160" target="_blank" >RIV/00216208:11160/14:10282160 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/14:10282160 RIV/60162694:G44__/14:43875049
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12191/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12191/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/1440-1681.12191" target="_blank" >10.1111/1440-1681.12191</a>

Result language
angličtina
Original language name
In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat
Original language description
1. Obidoxime, a weak acetylcholine-esterase (AChE) inhibitor, exerts muscarinic receptor antagonism with a significant muscarinic M2 receptor selective profile. 2. The current examinations aimed to determine the functional significance of muscarinic M2 receptors in the state of AChE inhibition, elucidating muscarinic M2 and M3 receptor interaction. 3. In the in vitro examinations, methacholine evoked concentration- dependent bladder contractile and atrial frequency inhibitory responses. Although atropine abolished both, methoctramine (1 mu mol/L) only affected the cholinergic response in the atrial preparations. 4. However, in the presence of methoctramine, physostigmine, an AChE inhibitor, increased the basal tension of the bladder strip preparations(+68%), as well as the contractile responses to low concentrations of methacholine (< 5 mu mol/L; + 90-290%). In contrast to physostigmine, obidoxime alone raised the basal tension (+58%) and the responses to low concentrations of methach
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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