Gold Sputtered Fiducial Markers for Combined Secondary Ion Mass Spectrometry and MALDI Imaging of Tissue Samples

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10293797" target="_blank" >RIV/00216208:11160/14:10293797 - isvavai.cz</a>

Result on the web

<a href="http://pubs.acs.org/doi/full/10.1021/ac500308s" target="_blank" >http://pubs.acs.org/doi/full/10.1021/ac500308s</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/ac500308s" target="_blank" >10.1021/ac500308s</a>

Result language

angličtina

Original language name

Gold Sputtered Fiducial Markers for Combined Secondary Ion Mass Spectrometry and MALDI Imaging of Tissue Samples

Original language description

Mass spectrometry imaging (MSI) is a label free technique capable of providing simultaneous identification and localization of biomolecules. A multimodal approach is required that allows for the study of the complexity of biological tissue samples to overcome the limitations of a single MSI technique. Secondary ion mass spectrometry (SIMS) allows for high spatial resolution imaging while matrix-assisted laser desorption (MALDI) offers a significantly wider mass range. The combination of coregistered SIMS and MALDI images results in detailed and unique biomolecular information. In this Technical Note, we describe how gold sputtered/implanted fiducial markers (FM) are created and can be used to ensure a proper overlay and coregistration of the two-dimensional images provided by the two MSI modalities.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Analytical Chemistry

ISSN

0003-2700

e-ISSN

—

Volume of the periodical

86

Issue of the periodical within the volume

14

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

6781-6785

UT code for WoS article

000339227400009

EID of the result in the Scopus database

—