The involvement of selected membrane transport mechanisms in the cellular uptake of Lu-177-labeled bombesin, somatostatin and gastrin analogues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10282208" target="_blank" >RIV/00216208:11160/15:10282208 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0969805114005071" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0969805114005071</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nucmedbio.2014.09.003" target="_blank" >10.1016/j.nucmedbio.2014.09.003</a>
Alternative languages
Result language
angličtina
Original language name
The involvement of selected membrane transport mechanisms in the cellular uptake of Lu-177-labeled bombesin, somatostatin and gastrin analogues
Original language description
Introduction: Radiolabeled receptor-targeting peptides are a useful tool for the diagnostic imaging and radiotherapy of some malignancies. However, the retention of radioactivity in the kidney may result in renal radiotoxic injury. This study seeks to evaluate the role of endocytic receptor megalin, renal SIC influx transporters and fluid phase endocytosis (FPE) in the cellular accumulation of radiolabeled peptides. Methods: In vitro transport cellular studies using megalin ligands (RAP, albumin), fluidphase endocytosis (FPE) inhibitor rottlerin and low temperature were employed to evaluate the transport mechanisms of the peptides. Cells transfected with hOAT1 or hOCT2 were used to analyze the role of these SLC transporters. Somatostatin (Lu-177-DOTA-[Tyr(3)]octreotate, Lu-177-DOTA-[1-Nal(3)]octreotide), gastrin (Lu-177-DOTA-sargastrin) and bombesin (Lu-177-DOTA-[Pro(1),Tyr(4)]bombesin, Lu-177-DOTA-[Lys(3)]bombesin, Lu-177-PCTA-[Lys(3)]bombesin) analogues were involved in the study. R
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nuclear Medicine and Biology
ISSN
0969-8051
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1-7
UT code for WoS article
000346947100001
EID of the result in the Scopus database
2-s2.0-84920598918