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The involvement of selected membrane transport mechanisms in the cellular uptake of Lu-177-labeled bombesin, somatostatin and gastrin analogues

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10282208" target="_blank" >RIV/00216208:11160/15:10282208 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0969805114005071" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0969805114005071</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.nucmedbio.2014.09.003" target="_blank" >10.1016/j.nucmedbio.2014.09.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The involvement of selected membrane transport mechanisms in the cellular uptake of Lu-177-labeled bombesin, somatostatin and gastrin analogues

  • Original language description

    Introduction: Radiolabeled receptor-targeting peptides are a useful tool for the diagnostic imaging and radiotherapy of some malignancies. However, the retention of radioactivity in the kidney may result in renal radiotoxic injury. This study seeks to evaluate the role of endocytic receptor megalin, renal SIC influx transporters and fluid phase endocytosis (FPE) in the cellular accumulation of radiolabeled peptides. Methods: In vitro transport cellular studies using megalin ligands (RAP, albumin), fluidphase endocytosis (FPE) inhibitor rottlerin and low temperature were employed to evaluate the transport mechanisms of the peptides. Cells transfected with hOAT1 or hOCT2 were used to analyze the role of these SLC transporters. Somatostatin (Lu-177-DOTA-[Tyr(3)]octreotate, Lu-177-DOTA-[1-Nal(3)]octreotide), gastrin (Lu-177-DOTA-sargastrin) and bombesin (Lu-177-DOTA-[Pro(1),Tyr(4)]bombesin, Lu-177-DOTA-[Lys(3)]bombesin, Lu-177-PCTA-[Lys(3)]bombesin) analogues were involved in the study. R

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/EE2.3.30.0061" target="_blank" >EE2.3.30.0061: Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nuclear Medicine and Biology

  • ISSN

    0969-8051

  • e-ISSN

  • Volume of the periodical

    42

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    1-7

  • UT code for WoS article

    000346947100001

  • EID of the result in the Scopus database

    2-s2.0-84920598918