Microwave-Assisted Synthesis of Pyrazinamide Derivatives: The Coupling Reaction of 3-Chloropyrazine-2-Carboxamide and Ring-Substituted Anilines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312035" target="_blank" >RIV/00216208:11160/15:10312035 - isvavai.cz</a>
Result on the web
<a href="http://benthamscience.com/journals/current-organic-synthesis/volume/12/issue/2/page/189/" target="_blank" >http://benthamscience.com/journals/current-organic-synthesis/volume/12/issue/2/page/189/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1570179411999141106101501" target="_blank" >10.2174/1570179411999141106101501</a>
Alternative languages
Result language
angličtina
Original language name
Microwave-Assisted Synthesis of Pyrazinamide Derivatives: The Coupling Reaction of 3-Chloropyrazine-2-Carboxamide and Ring-Substituted Anilines
Original language description
A new approach for aminodehalogenation reaction between 3-chloropyrazine-2-carboxamide and ring-substituted anilines is described. A series of 16 compounds (15 of them novel) derived from pyrazinamide have been synthesized successfully using the advantage of microwave-assisted reaction. The conditions for this aminodehalogenation reaction have been put to investigation to optimize the conversion, yield and time. The final methodology reduces the time needed for reaction from 24 hours using conventionalheating to 30 minutes under microwave irradiation and increases the yield. The synthetic procedure together with analytical data of all compounds is presented. Lipophilicity properties were calculated and experimentally determined.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Organic Synthesis
ISSN
1570-1794
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
2
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
8
Pages from-to
189-196
UT code for WoS article
000350751700009
EID of the result in the Scopus database
2-s2.0-84931031012