Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312164" target="_blank" >RIV/00216208:11160/15:10312164 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/15:33157021
Result on the web
<a href="http://benthamscience.com/journals/current-topics-in-medicinal-chemistry/volume/15/issue/9/page/830/" target="_blank" >http://benthamscience.com/journals/current-topics-in-medicinal-chemistry/volume/15/issue/9/page/830/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1568026615666150220112437" target="_blank" >10.2174/1568026615666150220112437</a>

Result language
angličtina
Original language name
Cardiovascular Effects of Coumarins Besides their Antioxidant Activity
Original language description
Coumarins are a large group of substances, primarily of plant origin. Like their more intensively examined congeners flavonoids, many of them are antioxidants. Although such properties may be advantageous in cardiovascular diseases, it has been shown that coumarins exhibit direct effects on the cardiovascular system which are not based on antioxidant activity. The most common example is the well-known drug warfarin, a synthetic compound derived from natural dicoumarol. Moreover, other coumarins have been shown to possess antiplatelet and vasodilatory potential. Interestingly, the former effect may be mediated by the inhibition of various pathways leading to platelet aggregation, their differing effects on those pathways being due to structural differences between the various coumarins. Conversely, their vasodilatory potential is linked in the majority of cases to the inhibition of increases in intracellular calcium concentration in vascular smooth muscle cells, and in several coumarins
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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