Synthesis and Antimicrobial Evaluation of 6-Alkylamino-N-phenylpyrazine-2-carboxamides

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312185" target="_blank" >RIV/00216208:11160/15:10312185 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/15:10312185

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/cbdd.12536/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/cbdd.12536/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cbdd.12536" target="_blank" >10.1111/cbdd.12536</a>

Result language

angličtina

Original language name

Synthesis and Antimicrobial Evaluation of 6-Alkylamino-N-phenylpyrazine-2-carboxamides

Original language description

This work presents synthesis and antimicrobial evaluation of nineteen 6-alkylamino-N-phenylpyrazine-2-carboxamides. Antimycobacterial activity was determined against Mycobacterium tuberculosis H37Rv, M.kansasii and two strains of M.avium. Generally, theantimycobacterial activity increased with prolongation of simple alkyl chain and culminated in compounds with heptylamino substitution (3e, 4e) with MIC=5-10m against M.tuberculosis H37Rv. On the contrary, derivatives with modified alkyl chain (containing e.g. terminal methoxy or hydroxy group) as well as phenylalkylamino derivatives were mainly inactive. The most active compounds (with hexyl to octylamino substitution) were evaluated for their in vitro activity against drug-resistant strains of M.tuberculosis and possessed activity comparable to that of the reference drug isoniazid. None of the tested compounds were active against M.avium. Some derivatives exhibited activity against Gram-positive bacteria including methicillin-resistan

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Biology and Drug Design

ISSN

1747-0277

e-ISSN

—

Volume of the periodical

86

Issue of the periodical within the volume

4

Country of publishing house

DK - DENMARK

Number of pages

8

Pages from-to

674-681

UT code for WoS article

000362163500031

EID of the result in the Scopus database

2-s2.0-84942503217