Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312236" target="_blank" >RIV/00216208:11160/15:10312236 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/15:43875397
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0367326X15000945" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0367326X15000945</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fitote.2015.04.004" target="_blank" >10.1016/j.fitote.2015.04.004</a>
Alternative languages
Result language
angličtina
Original language name
Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
Original language description
Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications. Thirty-one isoquinoline alkaloids of various structural types, previously isolated in our laboratory, were screened for their ability to inhibit prolyl oligopeptidase. Promising results have been showed by alkaloids californidine (IC50 = 55.6 +/- 3.5 mu M), dihydrosanquinarine (IC50 = 99.1 +/- 7.6 mu M), cotypalmine (IC50 = 128.0 +/- 10.5 mu M) and N-methyllaurotetanine (IC50 = 135.0 +/- 11.7 mu M).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fitoterapia
ISSN
0367-326X
e-ISSN
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Volume of the periodical
103
Issue of the periodical within the volume
June
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
192-196
UT code for WoS article
000356738800023
EID of the result in the Scopus database
2-s2.0-84927775062