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Isoquinoline alkaloids as prolyl oligopeptidase inhibitors

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312236" target="_blank" >RIV/00216208:11160/15:10312236 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/15:43875397

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0367326X15000945" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0367326X15000945</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.fitote.2015.04.004" target="_blank" >10.1016/j.fitote.2015.04.004</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Isoquinoline alkaloids as prolyl oligopeptidase inhibitors

  • Original language description

    Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications. Thirty-one isoquinoline alkaloids of various structural types, previously isolated in our laboratory, were screened for their ability to inhibit prolyl oligopeptidase. Promising results have been showed by alkaloids californidine (IC50 = 55.6 +/- 3.5 mu M), dihydrosanquinarine (IC50 = 99.1 +/- 7.6 mu M), cotypalmine (IC50 = 128.0 +/- 10.5 mu M) and N-methyllaurotetanine (IC50 = 135.0 +/- 11.7 mu M).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Fitoterapia

  • ISSN

    0367-326X

  • e-ISSN

  • Volume of the periodical

    103

  • Issue of the periodical within the volume

    June

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    5

  • Pages from-to

    192-196

  • UT code for WoS article

    000356738800023

  • EID of the result in the Scopus database

    2-s2.0-84927775062