Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312583" target="_blank" >RIV/00216208:11160/15:10312583 - isvavai.cz</a>
Result on the web
<a href="http://pubs.acs.org/doi/10.1021/mp500676e" target="_blank" >http://pubs.acs.org/doi/10.1021/mp500676e</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/mp500676e" target="_blank" >10.1021/mp500676e</a>
Alternative languages
Result language
angličtina
Original language name
Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules
Original language description
Hyaluronic acid (HA) hydrogels are interesting delivery systems for topical applications. Besides moisturizing the skin and improving wound healing, HA facilitates topical drug absorption and is highly compatible with labile biomacromolecules. Hence, inthis study we investigated the influence of HA hydrogels with different molecular weights (5 kDa, 100 kDa, 1 MDa) on the skin absorption of the model protein bovine serum albumin (BSA) using fluorescence lifetime imaging microscopy (FLIM). To elucidate the interactions of HA with the stratum corneum and the skin absorption of HA itself, we combined FLIM and Fourier-transform infrared (FTIR) spectroscopy. Our results revealed distinct formulation and skin-dependent effects. In barrier deficient (tape-stripped) skin, BSA alone penetrated into dermal layers. When BSA and HA were applied together, however, penetration was restricted to the epidermis. In normal skin, penetration enhancement of BSA into the epidermis was observed when applyin
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Pharmaceutics
ISSN
1543-8384
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1391-1401
UT code for WoS article
000354075700006
EID of the result in the Scopus database
2-s2.0-84929160348