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Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312583" target="_blank" >RIV/00216208:11160/15:10312583 - isvavai.cz</a>

  • Result on the web

    <a href="http://pubs.acs.org/doi/10.1021/mp500676e" target="_blank" >http://pubs.acs.org/doi/10.1021/mp500676e</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/mp500676e" target="_blank" >10.1021/mp500676e</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules

  • Original language description

    Hyaluronic acid (HA) hydrogels are interesting delivery systems for topical applications. Besides moisturizing the skin and improving wound healing, HA facilitates topical drug absorption and is highly compatible with labile biomacromolecules. Hence, inthis study we investigated the influence of HA hydrogels with different molecular weights (5 kDa, 100 kDa, 1 MDa) on the skin absorption of the model protein bovine serum albumin (BSA) using fluorescence lifetime imaging microscopy (FLIM). To elucidate the interactions of HA with the stratum corneum and the skin absorption of HA itself, we combined FLIM and Fourier-transform infrared (FTIR) spectroscopy. Our results revealed distinct formulation and skin-dependent effects. In barrier deficient (tape-stripped) skin, BSA alone penetrated into dermal layers. When BSA and HA were applied together, however, penetration was restricted to the epidermis. In normal skin, penetration enhancement of BSA into the epidermis was observed when applyin

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular Pharmaceutics

  • ISSN

    1543-8384

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    1391-1401

  • UT code for WoS article

    000354075700006

  • EID of the result in the Scopus database

    2-s2.0-84929160348