Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312695" target="_blank" >RIV/00216208:11160/15:10312695 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/15:50003973
Result on the web
<a href="http://pubs.acs.org/doi/10.1021/acs.jnatprod.5b00616" target="_blank" >http://pubs.acs.org/doi/10.1021/acs.jnatprod.5b00616</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jnatprod.5b00616" target="_blank" >10.1021/acs.jnatprod.5b00616</a>
Alternative languages
Result language
angličtina
Original language name
Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment
Original language description
AKR1B10 is an important human enzyme that participates in reduction of retinal, isoprenyl aldehydes as well as procarcinogens. It is indicated that AKR1B10 is implicated in the development of several cancers due to mentioned activities and it is regardedas a promising therapeutic target. Natural plant compounds (phenolic compounds and alkaloids) were investigated as potential inhibitors of AKR1B10. Flavones (apigenin, luteolin and 7-hydroxyflavone) were described as a new structural type of inhibitorsof AKR1B10. They significantly inhibited the the AKR1B10 activity also in intact cells without considerable cytotoxic effects. They can serve as model compounds for the design and future development of structurally related AKR1B10 inhibitors with even better characterstics.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Natural Products
ISSN
0163-3864
e-ISSN
—
Volume of the periodical
78
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
2666-2674
UT code for WoS article
000366005800020
EID of the result in the Scopus database
2-s2.0-84948823183