Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312754" target="_blank" >RIV/00216208:11160/15:10312754 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0890623815300010" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0890623815300010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.reprotox.2015.07.070" target="_blank" >10.1016/j.reprotox.2015.07.070</a>
Alternative languages
Result language
angličtina
Original language name
Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir
Original language description
Abacavir is as a frequent part of combination antiretroviral therapy used in pregnant women. The aim of this study was to investigate, using in vitro, in situ and ex vivo experimental approaches, whether the transplacental pharmacokinetics of abacavir isaffected by ATP-binding cassette (ABC) efflux transporters functionally expressed in the placenta: P-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2), multidrug resistance-associated protein 2 (ABCC2) and multidrug resistance-associated protein 5 (ABCC5). In vitro transport assays revealed that abacavir is a substrate of human ABCB1 and ABCG2 transporters but not of ABCC2 or ABCC5. In addition, in situ experiments using dually perfused rat term placenta confirmed interactions of abacavirwith placental Abcb1/Abcg2. In contrast, uptake studies in human placental villous fragments did not reveal any interaction of abacavir with efflux transporters suggesting a large contribution of passive diffusion and/or influx mechanisms
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Reproductive Toxicology
ISSN
0890-6238
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
November
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
176-182
UT code for WoS article
000360322300020
EID of the result in the Scopus database
2-s2.0-84939564335