Transkarbams: Transdermal Penetration-Enhancing Carbamates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10328168" target="_blank" >RIV/00216208:11160/15:10328168 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/chapter/10.1007/978-3-662-47039-8_19" target="_blank" >http://link.springer.com/chapter/10.1007/978-3-662-47039-8_19</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-662-47039-8_19" target="_blank" >10.1007/978-3-662-47039-8_19</a>
Alternative languages
Result language
angličtina
Original language name
Transkarbams: Transdermal Penetration-Enhancing Carbamates
Original language description
Transkarbams (TRANSdermal penetration-enhancing CARBAMates) are a structurally unusual class of compounds that facilitate drug delivery through the skin. These two-chain amphiphiles containing an ammonium carbamate polar head are formed by the reaction of omega-amino acid derivatives (in particular, 6-aminohexanoates) with carbon dioxide. Transkarbams, e.g., 6-dodecyloxy-6-oxohexylammonium 6-dodecyloxy-6-oxohexylcarbamate (transkarbam 12 or T12), are up to an order of magnitude more active than Azone(R) (N-dodecylazepan-2-one or laurocapram) in enhancing the percutaneous penetration of a broad spectrum of drugs.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP207%2F11%2F0365" target="_blank" >GAP207/11/0365: Synthesis and structure-activity relationships of skin ceramides and agents targeting them</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Percutaneous Penetration Enhancers: Chemical Methods in Penetration Enhancement
ISBN
978-3-662-47038-1
Number of pages of the result
15
Pages from-to
309-323
Number of pages of the book
411
Publisher name
Springer
Place of publication
Berlin
UT code for WoS chapter
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