Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10312764" target="_blank" >RIV/00216208:11160/16:10312764 - isvavai.cz</a>
Result on the web
<a href="http://www.tandfonline.com/doi/full/10.3109/00498254.2015.1086039" target="_blank" >http://www.tandfonline.com/doi/full/10.3109/00498254.2015.1086039</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/00498254.2015.1086039" target="_blank" >10.3109/00498254.2015.1086039</a>
Alternative languages
Result language
angličtina
Original language name
Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs)
Original language description
Purine cyclin-dependent kinase inhibitors have recently been recognised as promising candidates for the treatment of various cancers. We investigated transplacental passage of olomoucine II and purvalanol A in rat focusing on possible role of p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and/or multidrug resistance-associated proteins (ABCCs). Transplacental passage of olomoucine II and purvalanol A from mother to foetus is significantly reduced by active transporters, restricting thereby foetal exposure and providing protection against harmful effects of these xenobiotics.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F12%2F0850" target="_blank" >GAP303/12/0850: Transplacental pharmacokinetics of antiretroviral drugs; interactions with drug-efflux transporters</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Xenobiotica
ISSN
0049-8254
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
416-423
UT code for WoS article
000370621300004
EID of the result in the Scopus database
2-s2.0-84958103068