9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a Potentially Novel Antiplatelet Drug which Antagonizes the Effect of Thromboxane A(2)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10381842" target="_blank" >RIV/00216208:11160/18:10381842 - isvavai.cz</a>
Result on the web
<a href="http://www.ingentaconnect.com/content/ben/mc/2018/00000014/00000002/art00011" target="_blank" >http://www.ingentaconnect.com/content/ben/mc/2018/00000014/00000002/art00011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1573406413666171010102535" target="_blank" >10.2174/1573406413666171010102535</a>
Alternative languages
Result language
angličtina
Original language name
9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a Potentially Novel Antiplatelet Drug which Antagonizes the Effect of Thromboxane A(2)
Original language description
A series of xanthene-3-ones derivatives which were synthesized by us was tested for the antiplatelet activity. Initial screening showed that a majority of the synthesized derivatives had substantial antiplatelet potential. None of the compounds were able to block cyclooxygenase 1 or thromboxane synthase. The mechanism appeared to be based on antagonism of thromboxane effects. The most potent compound 9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one had better potential to block collagen induced platelet aggregation than clinically used acetylsalicylic acid.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicinal Chemistry
ISSN
1573-4064
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
200-209
UT code for WoS article
000424391200009
EID of the result in the Scopus database
2-s2.0-85042742824