Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10382850" target="_blank" >RIV/00216208:11160/18:10382850 - isvavai.cz</a>

Result on the web

<a href="http://pubs.rsc.org/en/content/articlehtml/2018/tb/c8tb01602j" target="_blank" >http://pubs.rsc.org/en/content/articlehtml/2018/tb/c8tb01602j</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c8tb01602j" target="_blank" >10.1039/c8tb01602j</a>

Result language

angličtina

Original language name

Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release

Original language description

Liposomes are able to load a range of cargos and have been used for drug delivery applications, including for stimuli-triggered drug release. Here, we describe an approach for imparting near infrared (NIR) light-triggered release to pre-formed liposomes, using a newly-synthesized cationic, amphiphilic phthalocyanine. When simply mixed in aqueous solution with cargo-loaded liposomes, the cationic amphiphilic phthalocyanine, but not a cationic hydrophilic azaphthalocyanine, spontaneously incorporates into the liposome bilayer. This enables the subsequent release of loaded cargo (doxorubicin or Basic Orange) upon irradiation with NIR light. The rate of release could be altered by varying the amount of photosensitizer added to the liposomes. In the absence of NIR light exposure, stable cargo loading of the liposomes was maintained.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/EF16_019%2F0000841" target="_blank" >EF16_019/0000841: Efficiency and safety improvement of current drugs and nutraceuticals: advanced methods - new challenges</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

44

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

7298-7305

UT code for WoS article

000450436700017

EID of the result in the Scopus database

2-s2.0-85055709935