Trophoblast: The central unit of fetal growth, protection and programming
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10382891" target="_blank" >RIV/00216208:11160/18:10382891 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1357272518302085" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1357272518302085</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biocel.2018.09.016" target="_blank" >10.1016/j.biocel.2018.09.016</a>
Alternative languages
Result language
angličtina
Original language name
Trophoblast: The central unit of fetal growth, protection and programming
Original language description
The placenta is the first organ to be created during mammalian development. As the main link between the mother and the fetus it has more diverse functions than any other organ, serving as a digestive, excretory, respiratory, endocrine, and immune system. The outer layer of the placenta, the trophoblast, plays a key role in fetal development by orchestrating all these functions. Recent research has associated perturbations of maternal conditions (such as malnutrition, stress or inflammation) with alterations of the trophoblasts' endocrine, transport and metabolic processes. As reviewed here, adaptations to these conditions enable the fetus to survive, but at the cost of permanently changing its physiology and structure. Moreover, these adaptations trigger fetal programming that increases predisposition to various pathological conditions in adult life, typically metabolic, cardiovascular or CNS diseases.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA17-16169S" target="_blank" >GA17-16169S: In vitro, in situ and ex vivo study of interactions of novel antiviral agents with drug transporters; effect on their passage across the placenta</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Biochemistry and Cell Biology
ISSN
1357-2725
e-ISSN
—
Volume of the periodical
105
Issue of the periodical within the volume
December
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
35-40
UT code for WoS article
000453642700005
EID of the result in the Scopus database
2-s2.0-85054461953