HPLC-MS/MS analysis of degradation products of neosalvarsan in 76-year-old injection preparation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F19%3A10397388" target="_blank" >RIV/00216208:11160/19:10397388 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10397388
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=DJoKnidfZ7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=DJoKnidfZ7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-019-02450-2" target="_blank" >10.1007/s00706-019-02450-2</a>

Result language
angličtina
Original language name
HPLC-MS/MS analysis of degradation products of neosalvarsan in 76-year-old injection preparation
Original language description
High-performance liquid chromatography hyphenated with tandem mass spectrometry (LC-MS/MS) was used to analyze a 76-year-old injection preparation of neosalvarsan. The sample constituents were separated on the reverse phase C18 by the optimized gradient elution of methanol and water. Using electrospray ionization in the negative mode (ESI-), the complete disintegration of neosalvarsan was proved. The structures of two degradation products of neosalvarsan, which are 2-(hydroxymethylamino)-4-arsenosophenol and As-(3-amino-4-hydroxyphenyl)arsonous acid were identified by MS2, and the ESI- fragmentation mechanism was proposed.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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