Sesquiterpenes alpha-humulene and beta-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F19%3A10408259" target="_blank" >RIV/00216208:11160/19:10408259 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/19:10408259
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=UOepGrlJ65" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=UOepGrlJ65</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/acph-2019-0003" target="_blank" >10.2478/acph-2019-0003</a>
Alternative languages
Result language
angličtina
Original language name
Sesquiterpenes alpha-humulene and beta-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells
Original language description
The present study is designed to find out if sesquiterpenes, alpha-humulene (HUM), valencene (VAL), beta-caryphylleneoxide (CAO) and trans-nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and oxaliplatin (1,2-diaminocyclohexa-neoxalato-platinum, OxPt), in colon cancer cell lines Caco-2 and SW-620. In addition, the possible mechanisms of sesquiterpene action are studied. The results show significant ability of HUM and especially of CAO to enhance the antiproliferative effects of FU and OxPt in cancer cell lines Caco-2 and SW-620. On the other hand, VAL and NER are ineffective. The action of CAO could be partly based on its ability to disrupt the mitochondrial membrane potential and to activate initiator caspases, but other mechanisms are probably also involved. Based on these results, CAO seems to have the potential for combination therapy of colon cancers and deserves further study.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Pharmaceutica
ISSN
1330-0075
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
1
Country of publishing house
HR - CROATIA
Number of pages
8
Pages from-to
121-128
UT code for WoS article
000452538800010
EID of the result in the Scopus database
2-s2.0-85058819383