Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10417797" target="_blank" >RIV/00216208:11160/20:10417797 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26310/20:PU139702
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RxFYmvrSf9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RxFYmvrSf9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12247-019-09387-3" target="_blank" >10.1007/s12247-019-09387-3</a>
Alternative languages
Result language
angličtina
Original language name
Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model
Original language description
Purpose Powder flow and packing behavior are among other factors determined by particle friction, which is traditionally measured in shear cells as the angle of internal friction (AIF). Considering that an AIF at a normal stress should be comparable to friction during tapping consolidation, this work aims at whether dynamic consolidation under gravity can be used to estimate an AIF. Methods Powder consolidation by controlled tapping was studied for seven commercially available types of lactose. A porosity factor was determined, and values were compared with the AIF obtained from Jenike shear cell measurements. Results Plotting porosity factor vs. number of applied taps provided an estimated angle of internal friction (AIF(E)) that was obtained from the slope of a linear relationship. A significant linear correlation (r = 0.825; p = 0.0223) was evidenced between AIF(E) and those AIF(J) estimated from linearized yield locus measurements of using the Jenike shear cell. Conclusions The good linear correlation between the angle of internal friction estimated from dynamic powder consolidation and the internal friction obtained by a shear cell is of high practical relevance. The latter shear cell behavior is only occasionally studied in the pharmaceutical industry, whereas dynamic powder tapping is a standard analysis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmaceutical Innovation
ISSN
1872-5120
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
380-391
UT code for WoS article
000560488800009
EID of the result in the Scopus database
2-s2.0-85073808220