Use of Precision-Cut Tissue Slices as a Translational Model to Study Host-Pathogen Interaction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F21%3A10434269" target="_blank" >RIV/00216208:11160/21:10434269 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=th~zr8uK96" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=th~zr8uK96</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fvets.2021.686088" target="_blank" >10.3389/fvets.2021.686088</a>

Result language

angličtina

Original language name

Use of Precision-Cut Tissue Slices as a Translational Model to Study Host-Pathogen Interaction

Original language description

The recent increase in new technologies to analyze host-pathogen interaction has fostered a race to develop new methodologies to assess these not only on the cellular level, but also on the tissue level. Due to mouse-other mammal differences, there is a desperate need to develop relevant tissue models that can more closely recapitulate the host tissue during disease and repair. Whereas organoids and organs-on-a-chip technologies have their benefits, they still cannot provide the cellular and structural complexity of the host tissue. Here, precision cut tissue slices (PCTS) may provide invaluable models for complex ex-vivo generated tissues to assess host-pathogen interaction as well as potential vaccine responses in a &quot;whole organ&quot; manner. In this mini review, we discuss the current literature regarding PCTS in veterinary species and advocate that PCTS represent remarkable tools to further close the gap between target identification, subsequent translation of results into clinical studies, and thus opening avenues for future precision medicine approaches.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Veterinary Science

ISSN

2297-1769

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

June

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

686088

UT code for WoS article

000662952100001

EID of the result in the Scopus database

2-s2.0-85108142448