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A review on pharmacological activities and synergistic effect of quercetin with small molecule agents

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F21%3A10434310" target="_blank" >RIV/00216208:11160/21:10434310 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=zpu2xC~~XL" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=zpu2xC~~XL</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.phymed.2021.153736" target="_blank" >10.1016/j.phymed.2021.153736</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A review on pharmacological activities and synergistic effect of quercetin with small molecule agents

  • Original language description

    Background: Quercetin is a natural flavonoid, which widely exists in nature, such as tea, coffee, apples, and onions. Numerous studies have showed that quercetin has multiple biological activities such as anti-oxidation, anti-inflammatory, and anti-aging. Hence, quercetin has a significant therapeutic effect on cancers, obesity, diabetes, and other diseases. In the past decades, a large number of studies have shown that quercetin combined with other agents can significantly improve the overall therapeutic effect, compared to single use. Purpose: This work reviews the pharmacological activities of quercetin and its derivatives. In addition, this work also summarizes both in vivo and in vitro experimental evidence for the synergistic effect of quercetin against cancers and metabolic diseases. Methods: An extensive systematic search for pharmacological activities and synergistic effect of quercetin was performed considering all the relevant literatures published until August 2021 through the databases including NCBI PubMed, Scopus, Web of Science, and Google Scholar. The relevant literatures were extracted from the databases with following keyword combinations: &quot;pharmacological activities&quot; OR &quot;biological activities&quot; OR &quot;synergistic effect&quot; OR &quot;combined&quot; OR &quot;combination&quot; AND &quot;quercetin&quot; as well as free-text words. Results: Quercetin and its derivatives possess multiple pharmacological activities including anti-cancer, antioxidant, anti-inflammatory, anti-cardiovascular, anti-aging, and neuroprotective activities. In addition, the synergistic effect of quercetin with small molecule agents against cancers and metabolic diseases has also been confirmed. Conclusion: Quercetin cooperates with agents to improve the therapeutic effect by regulating signal molecules and blocking cell cycle. Synergistic therapy can reduce the dose of agents and avoid the possible toxic and side effects in the treatment process. Although quercetin treatment has some potential side effects, it is safe under the expected use conditions. Hence, quercetin has application value and potential strength as a clinical drug. Furthermore, quercetin, as the main effective therapeutic ingredient in traditional Chinese medicine, may effectively treat and prevent coronavirus disease 2019 (COVID-19).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Phytomedicine

  • ISSN

    0944-7113

  • e-ISSN

  • Volume of the periodical

    92

  • Issue of the periodical within the volume

    November

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    10

  • Pages from-to

    153736

  • UT code for WoS article

    000703823800021

  • EID of the result in the Scopus database

    2-s2.0-85115147869