A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F23%3A10471101" target="_blank" >RIV/00216208:11160/23:10471101 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dL8E.Od5MQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dL8E.Od5MQ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1871530322666221006144449" target="_blank" >10.2174/1871530322666221006144449</a>
Alternative languages
Result language
angličtina
Original language name
A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators
Original language description
Cobalt is an essential trace element, but it can also rarely cause cobalt toxicity. There are no approved selective cobalt chelators. This study aimed to develop a simple and complex methodological approach for screening potential cobalt chelators and evaluating the potential toxicity. A simple spectrophotometric assay employing 1-nitroso-2-naphthol-3,6-disulfonic acid disodium salt (NNDSA) for screening cobalt chelation was standardized and the suitability of the method was verified using four known metal chelators. The potential toxicity of cobalt-chelator complexes was also determined by employing a novel HPLC method with coulometric detection. The effect on erythrocyte haemolysis was tested as well. The described complex methodological approach could serve as a simple yet precise tool for evaluating novel, effective and safe cobalt chelators.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/EF19_073%2F0016935" target="_blank" >EF19_073/0016935: Grant schemes at Charles University</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicinal Chemistry
ISSN
1573-4064
e-ISSN
1875-6638
Volume of the periodical
19
Issue of the periodical within the volume
5
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
13
Pages from-to
495-507
UT code for WoS article
001004020500009
EID of the result in the Scopus database
2-s2.0-85153881663