Effects of imidazolium ionic liquids on skin barrier lipids - Perspectives for drug delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F24%3A10480106" target="_blank" >RIV/00216208:11160/24:10480106 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3vSS9-MkLN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3vSS9-MkLN</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcis.2023.12.139" target="_blank" >10.1016/j.jcis.2023.12.139</a>
Alternative languages
Result language
angličtina
Original language name
Effects of imidazolium ionic liquids on skin barrier lipids - Perspectives for drug delivery
Original language description
Ionic liquids (ILs) have great potential to facilitate transdermal and topical drug delivery. Here, we investigated the mechanism of action of amphiphilic ILs 1-methyl-3-octylimidazolium bromide (C(8)MIM) and 3-dodecyl-1-methylimidazolium bromide (C(12)MIM) in skin barrier lipid models in comparison to their complex effects in human skin. C(8)MIM incorporated in a skin lipid model was a better permeation enhancer than C(12)MIM for water and model drugs, theophylline and diclofenac. Solid state 2H NMR and X-ray diffraction indicated that both ILs prefer the cholesterol-rich regions in skin lipids without significantly perturbing their lamellar arrangement and that C(8)MIM induces the formation of an isotropic lipid phase to a greater extent compared to C(12)MIM. C(12)MIM applied topically to the lipid model or human skin as a pretreatment was more potent than C(8)MIM. When co-applied with the drugs to human skin, aqueous C(12)MIM was more potent than C(8)MIM in enhancing theophylline permeation, but neither IL affected (even decreased) diclofenac permeation. Thus, the IL's ability to permeabilize skin lipid barrier is strongly modulated by its ability to reach the site of action and its interactions with drug and solvent. Such an interplay is far from trivial and requires detailed investigation to realize the full potential of ILs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Colloid and Interface Science
ISSN
0021-9797
e-ISSN
1095-7103
Volume of the periodical
659
Issue of the periodical within the volume
April
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
449-462
UT code for WoS article
001154614100001
EID of the result in the Scopus database
2-s2.0-85182890369