Small phenolic compounds as potential endocrine disruptors interacting with estrogen receptor alpha
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F24%3A10486724" target="_blank" >RIV/00216208:11160/24:10486724 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=IxPZeRjlj_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=IxPZeRjlj_</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fendo.2024.1440654" target="_blank" >10.3389/fendo.2024.1440654</a>
Alternative languages
Result language
angličtina
Original language name
Small phenolic compounds as potential endocrine disruptors interacting with estrogen receptor alpha
Original language description
The human body is regularly exposed to simple catechols and small phenols originating from our diet or as a consequence of exposure to various industrial products. Several biological properties have been associated with these compounds such as antioxidant, anti-inflammatory, or antiplatelet activity. Less explored is their potential impact on the endocrine system, in particular through interaction with the alpha isoform of the estrogen receptor (ER alpha). In this study, human breast cancer cell line MCF-7/S0.5 was employed to investigate the effects on ER alpha of 22 closely chemically related compounds (15 catechols and 7 phenols and their methoxy derivatives), to which humans are widely exposed. ER alpha targets genes ESR1 (ER alpha) and TFF1, both on mRNA and protein level, were chosen to study the effect of the tested compounds on the mentioned receptor. A total of 7 compounds seemed to impact mRNA and protein expression similarly to estradiol (E2). The direct interaction of the most active compounds with the ER alpha ligand binding domain (LBD) was further tested in cell-free experiments using the recombinant form of the LBD, and 4-chloropyrocatechol was shown to behave like E2 with about 1/3 of the potency of E2. Our results provide evidence that some of these compounds can be considered potential endocrine disruptors interacting with ER alpha.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Endocrinology
ISSN
1664-2392
e-ISSN
1664-2392
Volume of the periodical
15
Issue of the periodical within the volume
October
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
1440654
UT code for WoS article
001348531000001
EID of the result in the Scopus database
2-s2.0-85208620426