Rapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelators
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F24%3A10487138" target="_blank" >RIV/00216208:11160/24:10487138 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=AB8bt3Uj34" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=AB8bt3Uj34</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00775-024-02078-6" target="_blank" >10.1007/s00775-024-02078-6</a>
Alternative languages
Result language
angličtina
Original language name
Rapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelators
Original language description
The aim of this study was to develop an affordable, rapid but sensitive and precise method for determining the degree of chelation of calcium and magnesium ions. Spectrophotometric method using o-cresolphthalein complexone (o-CC) was developed and its biological relevance was confirmed in human platelets by impedance aggregometry. The method was developed and validated. Four and seven out of twenty-one chelators strongly chelated calcium and magnesium ions, respectively. Structure-activity relationships for eight quinolin-8-ols showed improvements in chelation particularly in the cases of dihalogen substitution, and a negative linear relationship between pKa and magnesium chelation was observed. Calcium chelation led to inhibition of platelet aggregation in concentrations corresponding to the complex formation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/EH22_008%2F0004607" target="_blank" >EH22_008/0004607: New Technologies for Translational Research in Pharmaceutical Sciences /NETPHARM</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Inorganic Chemistry
ISSN
0949-8257
e-ISSN
1432-1327
Volume of the periodical
29
Issue of the periodical within the volume
7-8
Country of publishing house
DE - GERMANY
Number of pages
16
Pages from-to
785-800
UT code for WoS article
001335353500002
EID of the result in the Scopus database
2-s2.0-85207301546