Enhanced photodynamic activity of asymmetric non-ionic Zn(II) phthalocyanine amphiphiles: Effect of molecular design on In vitro activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F24%3A10487533" target="_blank" >RIV/00216208:11160/24:10487533 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3t_lhTX14S" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3t_lhTX14S</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dyepig.2023.111809" target="_blank" >10.1016/j.dyepig.2023.111809</a>
Alternative languages
Result language
angličtina
Original language name
Enhanced photodynamic activity of asymmetric non-ionic Zn(II) phthalocyanine amphiphiles: Effect of molecular design on In vitro activity
Original language description
We herein introduce the rational design, synthesis, and photophysical characterizations of three asymmetric Zn(II)Pcs (Pc-Glu4, Pc-Mal4, and Pc-PEG4) bearing four neutral hydrophilic substituents, namely glucosyl, maltosyl, and PEG, on the macrocyclic dual rims. The photodynamic activity of the attained structures, as compared to their fully derivatized hydrophilic versions (hexadeca-glucosylated Pc-Glu16 and PEGylated Pc-PEG16 and AzaPc-PEG16), on several cell lines, e.g., HeLa, SK-MEL-28, MCF-7, was investigated. Results revealed that the newly designed macrocycles were characterized by higher photodynamic activity with EC50 values in (sub) micromolar ranges, which is about two orders of magnitude better than for symmetric hydrophilic counterparts. This has been attributed to their higher uptake by cells as well as their significant interaction with bovine serum albumin and biomembranes. A preserved photodynamic activity during the treatment without incubation on endothelial cell lines (HUVEC and EA.hy928) was detected for the asymmetrical gluco-macrocycles, indicating a good potential for vascular-targeted PDT.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GJ19-14758Y" target="_blank" >GJ19-14758Y: Novel photosensitizers for vascular targeted photodynamic therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dyes and Pigments
ISSN
0143-7208
e-ISSN
1873-3743
Volume of the periodical
221
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
111809
UT code for WoS article
001125412400001
EID of the result in the Scopus database
2-s2.0-85177859535