Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10497202" target="_blank" >RIV/00216208:11160/25:10497202 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/25:43932845
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rPm0fcIfbw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rPm0fcIfbw</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11101-025-10102-z" target="_blank" >10.1007/s11101-025-10102-z</a>
Alternative languages
Result language
angličtina
Original language name
Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review
Original language description
This review provides a comprehensive overview of the alkaloids in the genus Vinca L. (Apocynaceae), which is renowned for its rich content of monoterpene indole alkaloids and widespread occurrence in Europe, northwest Africa, and southwest Asia. By consolidating extensive phytochemical and pharmacological research in five phytochemically investigated species within the genus Vinca L., it highlights 202 identified alkaloids - categorized into 20 structural groups - and emphasizes their structural diversity and biological activities. These alkaloids, including notable compounds such as vincamine and reserpine, exhibit a range of biological activities, including antitumor, anti-Alzheimer, antibacterial, and antihypertensive effects. The review also explores biosynthetic pathways, key structural classes (aspidosperma, corynanthe, iboga, yohimbe, strychnos), and the structural and biological complexities surrounding these alkaloids. Additionally, it provides a botanical perspective on Vinca species, underscoring both their historical and current medicinal uses. Overall, the genus Vinca emerges as a valuable source of bioactive compounds, with significant potential for future pharmacognostic and drug development research, particularly in oncology and neurodegenerative diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/EH22_008%2F0004607" target="_blank" >EH22_008/0004607: New Technologies for Translational Research in Pharmaceutical Sciences /NETPHARM</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Phytochemistry Reviews
ISSN
1568-7767
e-ISSN
1572-980X
Volume of the periodical
24
Issue of the periodical within the volume
5
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
71
Pages from-to
3665-3735
UT code for WoS article
001456111700001
EID of the result in the Scopus database
2-s2.0-105001793945