Yohimbine stability: analysis of its several decades-old pharmaceutical products and forced degradation study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10504904" target="_blank" >RIV/00216208:11160/25:10504904 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10504904
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R1Zgp4KHsC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R1Zgp4KHsC</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-025-03352-2" target="_blank" >10.1007/s00706-025-03352-2</a>
Alternative languages
Result language
angličtina
Original language name
Yohimbine stability: analysis of its several decades-old pharmaceutical products and forced degradation study
Original language description
Yohimbine is an indole alkaloid traditionally used as an aphrodisiac and currently present in various pharmaceutical preparations and herbal dietary supplements. Despite the long history of yohimbine use, stability data for yohimbine in pharmaceutical products remain limited. In this study, we investigated the long-term stability of yohimbine by analyzing five several decades-old pharmaceutical products (three solid formulations and two injectable solutions) dating from the 1930s to the 1970s. Reversed-phase HPLC with UV and tandem mass spectrometric detection was used for compound identification and quantification. Additionally, a forced degradation study was conducted to evaluate the hydrolytic and oxidative stability of yohimbine under various conditions. The results confirm the remarkable stability of yohimbine in solid formulations. In contrast, significant degradation leading to the formation of yohimbinic acid was observed in acidic injectable solutions.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Monatshefte für Chemie - Chemical Monthly
ISSN
0026-9247
e-ISSN
1434-4475
Volume of the periodical
156
Issue of the periodical within the volume
10
Country of publishing house
AT - AUSTRIA
Number of pages
9
Pages from-to
1027-1035
UT code for WoS article
001541712900001
EID of the result in the Scopus database
2-s2.0-105012274380