A novel bisphenol A alternative, DD-70, may negatively affect haemostasis through cyclooxygenase 1 inhibition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10504976" target="_blank" >RIV/00216208:11160/25:10504976 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=k36Iby-J9o" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=k36Iby-J9o</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.envint.2025.109738" target="_blank" >10.1016/j.envint.2025.109738</a>
Alternative languages
Result language
angličtina
Original language name
A novel bisphenol A alternative, DD-70, may negatively affect haemostasis through cyclooxygenase 1 inhibition
Original language description
Bisphenols have been recognized as environmental pollutants. Bans on bisphenol A use led to the replacement by alternatives. There are, however, almost no data on their biological effects. This study has focused on the potential negative impact of four alternatives to bisphenol A on haemostasis and erythrocytes. The erythrocyte toxicity of all tested compounds was relatively low, with TC50s above 500 microM in all cases. None of the compounds augmented platelet aggregation, but DD-70 was a potent antiplatelet compound with an IC50 of 5.0 +/- 2.7 microM in arachidonic acid-triggered platelet aggregation. DD-70 also blocked other aggregation pathways, and its mechanism was primarily based on the inhibition of cyclooxygenase 1. Only high concentrations of the tested bisphenol A alternatives (>= 100 microM) influenced blood coagulation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GF24-12943K" target="_blank" >GF24-12943K: Bisphenol A substitutes: health risks to the endocrine and cardiovascular systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environment International
ISSN
0160-4120
e-ISSN
1873-6750
Volume of the periodical
203
Issue of the periodical within the volume
September
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
109738
UT code for WoS article
001563970900005
EID of the result in the Scopus database
2-s2.0-105014294878