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Synthesis of Linear and Branched Regioisomeric Chitooligosaccharides as Potential Mimetics of Natural Killer Cells NKR-P1 and CD69 Lectin Receptor

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F04%3A00006389" target="_blank" >RIV/00216208:11310/04:00006389 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis of Linear and Branched Regioisomeric Chitooligosaccharides as Potential Mimetics of Natural Killer Cells NKR-P1 and CD69 Lectin Receptor

  • Original language description

    Regioisomer of chitobiose 13 with beta(1-->3) glycosidic bond and branched analog of chitotriose 25 having beta(1-->4) and beta(1-->3) glycosidic bonds, were prepared and tested as potential mimetics of natural oligosaccharide ligands for activating lectin receptors NKR-P1A and CD69 of natural killer (NK) cells. The structural requirements of NKR-P1 lectin receptor on effective mimetics of its natural ligands has been discussed. A significant binding activity of the branched trisaccharide 25 to the receptor CD69 was observed.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA203%2F00%2F0071" target="_blank" >GA203/00/0071: Synthesis of cyclic oligosaccharides containing 2-amino-2-deoxy-hexopyranoses and study of their complexation activity</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Collection of Czechoslovak Chemical Communications

  • ISSN

    0010-0765

  • e-ISSN

  • Volume of the periodical

    69

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    24

  • Pages from-to

  • UT code for WoS article

    000224406800003

  • EID of the result in the Scopus database