Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F07%3A12201" target="_blank" >RIV/00216208:11310/07:12201 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/07:1577 RIV/00216208:11130/07:1577
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine
Original language description
This is the first report on the molecular mechanism of ellipticine oxidation by peroxidases (human myeloperoxidase, human and ovine cyclooxygenases, bovine lactoperoxidase, horseradish peroxidase) to species forming ellipticine-DNA adducts.
Czech name
Peroxidasy aktivují protinádorové léčivo ellipticin na intermediaty tvořící deoxyguanosinové adukty s DNA, identické s adukty nalezenými in vivo a generovanými z 12-hydroxyellipticinu a 13-hydroxyellipticinu
Czech description
Článek je prvn informací o molekulárním mechanismu oxidace ellipticinu peroxidasami (lidskou myeloperoxidasou, lidskou a ovčí cyklooxygenasou, hovězí laktoperoxidasou, křenovou peroxidasou) na intermediáty tvořící adukty ellipticinu s DNA.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F06%2F0329" target="_blank" >GA203/06/0329: Study on mechanism of antineoplastic action of an anticancer drug ellipticine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of cancer
ISSN
0020-7136
e-ISSN
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Volume of the periodical
120
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
243-251
UT code for WoS article
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EID of the result in the Scopus database
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