Stimuli-Responsive Nanoparticles Based on Interaction of Metallacarborane with Poly(ethylene oxide)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10000134" target="_blank" >RIV/00216208:11310/09:10000134 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/09:00327533 RIV/61388963:_____/09:00327533
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Stimuli-Responsive Nanoparticles Based on Interaction of Metallacarborane with Poly(ethylene oxide)
Original language description
The antiviral active boron cluster [3-cobalt bis(1,2-dicarbollide)](-1) anion, CoD, interacts and forms a stable complex with one of the most widely used polymeric component of drug delivery systems: poly(ethylene oxide), PEO. The formation of insolubleNaCoD/PEO complex can be exploited in design of water-soluble metallacarborane-containing nanoparticles that could offer applications in medicine. We studied the boron cluster interaction with a hydrophilic block copolymer: poly(ethylene oxide)-block-poly(methacrylic acid), PEO-PMA. The interaction leads to a spontaneous formation of core-shell nanoparticles. The insoluble core contains the PEO/CoD complex, while the polyanionic PMA blocks, which do not interact with the metallacarborane, form the pH-responsive micellar shell and stabilize the particles in aqueous media.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecules
ISSN
0024-9297
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
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UT code for WoS article
000268138500068
EID of the result in the Scopus database
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