Sex in Leishmania

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10000154" target="_blank" >RIV/00216208:11310/09:10000154 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sex in Leishmania
Original language description
Genetic exchange is crucial for adaptation to stressful environments. However, in Leishmania, exposure to specific stressful conditions in the sand fly gut is likely to induce genetic exchange. Access to the sand fly genome is now urgently required to facilitace the search for factors that stimulate Leishmania sex. The epidemiological consequences of genetic exchange in Leishmania are potentially alarming. Akopyants et al. demonstrate two distinct virulence traits among hybrid Leishmania clones but do not dokument the effect of genetic exchange on development of Leishmania in the vector. There is, however, proof that sex enhances Leishmania fitness and transmission in the sand fly. Leishmania infantum and L. major are divergent species, transmitted bydifferent vectors to different mammalian reservoirs. Nevertheless, L. infantum/L. major hybrids complete the life cycle in Phlebotomus papatasi, the specific vector of L. major that does not support L. infantum.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/LC06009" target="_blank" >LC06009: Centre for molecular ecology of vectors and pathogens</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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