Voltammetric Determination of Azidothymidine Using Silver Solid Amalgam Electrodes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10000209" target="_blank" >RIV/00216208:11310/09:10000209 - isvavai.cz</a>

Alternative codes found

RIV/61388955:_____/09:00328330

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Voltammetric Determination of Azidothymidine Using Silver Solid Amalgam Electrodes

Original language description

A new simple and direct electroanalytical method was developed for the determination of azidothymidine in commercial pharmaceutical preparations. It is based on differential pulse voltammetry at silver solid amalgam electrode with polished surface (p-AgSAE) or surface modified by mercury meniscus (m-AgSAE). The electroreduction of azidothymidine in basic media at these electrodes gives rise to one irreversible cathodic peak. Its potential in 0.05 mol L-1 borate buffer, pH 9.3 at ca. - 1050 mV is comparable to that using hanging mercury drop electrode (HMDE). Achieved limits of quantitation are in the 10(-7) mol L-1 concentration range for both amalgam electrodes. According to the procedure based on the standard addition technique, the recoveries of known amounts of azidothymidine contained in pharmaceutical preparations available in capsules were 101.4 +/- 1.8% (m-AgSAE), 100.3 +/- 3.5% (p-AgSAE) and 102.0 +/- 1.0% (HMDE) (n = 10).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electroanalysis

ISSN

1040-0397

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

15

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

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UT code for WoS article

000268790300013

EID of the result in the Scopus database

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